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Phase 2 EQUATOR Abstracts Demonstrating Ability in Psoriatic Arthritis Additionally Presented in a Absolute Affair at 2018 ACR/ARHP Anniversary Meeting 

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Chicago, October 22, 2018; 19.15 CET – Gilead Sciences, Inc. (GILD) and Galapagos NV (Euronext & NASDAQ: GLPG) today appear that abundant after-effects from two analytic trials evaluating filgotinib, an investigational, careful JAK1 inhibitor, for the analysis of psoriatic arthritis and ankylosing spondylitis were both appear in The Lancet. The advertisement of the Appearance 2 EQUATOR abstracts additionally coincides with a absolute affair presentation at the 2018 American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP) Anniversary Meeting.

“The after-effects of the EQUATOR and TORTUGA studies authenticate that filgotinib bigger the signs and affection of patients with psoriatic arthritis whose ache had not responded to above-mentioned therapies and independently, for those with ankylosing spondylitis,” said John McHutchison, AO, MD, Chief Scientific Officer and Head of Analysis and Development, Gilead Sciences. “These allegation represent an important footfall advanced in our efforts to advance outcomes for bodies alive with these anarchic diseases.”

“We are admiring that filgotinib demonstrates a constant assurance and ability contour beyond assorted anarchic conditions, including psoriatic arthritis and ankylosing spondylitis,” said Dr. Walid Abi-Saab, Chief Medical Officer at Galapagos. “We attending advanced to administration added updates as we abide to advance this admixture for patients in charge of added analysis options.”

Phase 2 EQUATOR Abstraction in Psoriatic Arthritis [ACR/ARHP Abstract #1821]

Data from EQUATOR, a placebo-controlled balloon of 131 adults with moderately to acutely alive psoriatic arthritis who had an bare acknowledgment or were antipathetic to at atomic one accepted disease-modifying anti-rheumatic biologic (cDMARD), accustomed the ability of filgotinib in this accommodating population. The abstraction accomplished its primary endpoint at Week 16, with 80 percent of patients on filgotinib 200mg once-daily accomplishing ACR20, compared with 33 percent on placebo (p<0.001). ACR50 and ACR70 responses at Week 16 were additionally decidedly college for filgotinib compared with placebo (ACR50: 48 percent for filgotinib vs 15 percent, p<0.001; ACR70: 23 percent vs 6 percent, p<0.01). These abstracts were ahead appear in May 2018.

The abstraction additionally begin greater advance in ache signs and affection for patients accepting filgotinib 200mg once-daily compared with placebo at Week 16, as abstinent by Minimal Ache Activity (MDA) (23 percent vs 9 percent, p<0.05) and the Crawling Area and Severity Basis 75 percent advance from baseline (PASI75) (45 percent vs 15 percent, p<0.01). The abstracts showed greater advance from baseline in the Health appraisal check affliction basis (HAQ-DI) for those accepting filgotinib compared with placebo (-0.57 vs -0.28, p<0.001).

Safety-related outcomes were agnate amid the filgotinib and placebo accoutrements of the study, including ante of treatment-emergent adverse contest (57 percent and 59 percent, respectively) and infections and infestations (22 percent and 21 percent). Two austere treatment-emergent adverse contest were reported: one hip breach in the placebo accumulation and one case of baleful pneumonia in the filgotinib analysis group, which was the alone austere infection and the alone afterlife in the study. No abysmal venous thrombosis, pulmonary emism, malignancies, gastrointestinal perforations, adept infections/active tuberculosis, or cases of Herpes zoster were reported.

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“Effective analysis for psoriatic arthritis is analytical for abating affliction and deepening and allowance to anticipate collective damage.  Unfortunately, not all patients acknowledge to currently accessible therapies,” said Philip J. Mease, MD, Director of Rheumatology Research, Swedish-Providence-St. Joseph Health Systems and Analytic Professor, University of Washington. “These after-effects announce that filgotinib has the abeyant to abode the needs of individuals who crave added analysis options.”

Phase 2 TORTUGA Abstraction in Ankylosing Spondylitis

In the Appearance 2 TORTUGA study, adults with moderately to acutely alive ankylosing spondylitis who were brash with filgotinib 200mg once-daily accomplished decidedly greater improvements in AS Ache Activity Score (ASDAS), the primary endpoint, at Week 12. The beggarly change from baseline in ASDAS was -1.5 for patients brash with filgotinib against -0.6 for those brash with placebo (p<0.0001). ASAS20 and ASAS40 responses at Week 12 were additionally decidedly college for filgotinib compared with placebo (ASAS20: 76 percent for filgotinib vs 40 percent for placebo, p<0.0001; ASAS40: 38 percent vs 19 percent, p<0.05).

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Adverse contest were about balmy or abstinent in severity and were appear in an according admeasurement of patients in the filgotinib and placebo groups (31 percent). Laboratory changes were constant with those ahead appear for filgotinib, and no new assurance signals were empiric in the study. There was one treatment-emergent austere adverse accident of pneumonia appear for a accommodating accepting filgotinib who recovered afterwards hospital-based antibacterial treatment. One accommodating with an affiliated accident for occlusion who was randomized to filgotinib accomplished a non-serious abysmal venous occlusion afterwards commutual the advance of abstraction drug. No deaths, malignancies, hepatic events, gastrointestinal perforations, adept infections/active tuberculosis, or cases of Herpes zoster were reported.

Full after-effects of both studies are now accessible in The Lancet:

Efficacy and assurance of filgotinib, a careful Janus kinase 1 inhibitor, in patients with alive psoriatic arthritis (EQUATOR): after-effects from a randomised, placebo-controlled, appearance 2 trial: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32483-8/fulltext

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Efficacy and assurance of filgotinib, a careful Janus kinase 1 inhibitor, in patients with alive ankylosing spondylitis (TORTUGA): after-effects from a randomised, placebo-controlled, appearance 2 trial: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32463-2/fulltext

Filgotinib is investigational and not accustomed anywhere globally. Its ability and assurance accept not been established.  For advice about the analytic trials with filgotinib: www.clinicaltrials.gov.

About the EQUATOR TrialInitiated by Galapagos in April 2017, the EQUATOR Appearance 2 balloon was a multi-center, randomized, double-blind, placebo-controlled balloon to appraise the assurance and ability of filgotinib in developed patients with moderately to acutely alive psoriatic arthritis who had an bare acknowledgment or were antipathetic to accepted disease-modifying anti-rheumatic drugs (cDMARDs). EQUATOR was conducted in Ukraine, Poland, Estonia, Bulgaria, Spain, Czech Republic and Belgium. In total, 131 patients were randomized in a 1:1 arrangement to accept once-daily articulate filgotinib 200mg or placebo for 16 weeks; 85 percent of the patients were naïve to anti-TNF treatments.

The primary cold of EQUATOR was to appraise the aftereffect of filgotinib compared to placebo on the signs and affection of psoriatic arthritis, as adjourned by the admeasurement of patients accomplishing ACR20 at Week 16. Secondary objectives included the admeasurement of patients accomplishing ACR50/70 and MDA as able-bodied as the furnishings of filgotinib on psoriasis, dactylitis (whole feel inflammation), and enthesitis (inflammation of the tendons).

About the TORTUGA StudyTORTUGA was a multi-center, randomized, double-blind, placebo-controlled, Appearance 2 abstraction to appraise the assurance and ability of filgotinib in developed patients with moderately to acutely alive AS. The balloon was conducted in Belgium, Bulgaria, Czech Republic, Estonia, Poland, Spain and Ukraine. In total, 116 patients were randomized in a 1:1 arrangement to accept filgotinib 200 mg or placebo already circadian for 12 weeks. The primary cold of TORTUGA was to appraise the aftereffect of filgotinib compared to placebo on the signs and affection of AS, as adjourned at Week 12 by ASDAS (a accepted blended basis for assessing the disease, which incorporates bristles ache activity variables).

About the Galapagos – Gilead Collaboration

Galapagos and Gilead entered into a all-around accord for the development and commercialization of filgotinib in anarchic indications.  Filgotinib is actuality brash in several analytic trials in anarchic diseases, including the Appearance 3 trials in rheumatoid arthritis FINCH 1, 2 and 3, the EQUATOR Appearance 2 affairs in psoriatic arthritis, the TORTUGA abstraction in ankylosing spondylitis, the DIVERSITY Appearance 3 balloon in Crohn’s ache (also baby bowel and fistulizing Crohn’s ache Appearance 2 studies) and the Appearance 3 SELECTION balloon in ulcerative colitis.

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About Galapagos

Galapagos (Euronext & NASDAQ: GLPG) is a clinical-stage biotechnology aggregation specialized in the analysis and development of baby atom medicines with atypical modes of action. Galapagos’ activity comprises Appearance 3 through to analysis programs in inflammation, fibrosis, cystic fibrosis, osteoarthritis and added indications. Our ambition analysis belvedere has delivered three atypical mechanisms assuming able accommodating after-effects in, respectively, anarchic diseases, idiopathic pulmonary fibrosis and atopic dermatitis.  Galapagos is focused on the development and commercialization of atypical medicines that will advance people’s lives. The Galapagos group, including fee-for-service accessory Fidelta, has about 675 employees, operating from its Mechelen, Belgium address and accessories in the Netherlands, France, Switzerland, the US and Croatia.  More advice at www.glpg.com.

About Gilead SciencesGilead Sciences, Inc. is a research-based biopharmaceutical aggregation that discovers, develops and commercializes avant-garde medicines in areas of unmet medical need. The aggregation strives to transform and abridge affliction for bodies with life-threatening illnesses about the world. Gilead has operations in added than 35 countries worldwide, with address in Foster City, California. For added advice on Gilead Sciences, amuse appointment the company’s website at www.gilead.com.

Galapagos Forward-Looking StatementThis absolution may accommodate advanced statements with account to Galapagos, including statements apropos Galapagos’ cardinal ambitions, the apparatus of activity and abeyant assurance and ability of filgotinib, the advancing timing of analytic studies with filgotinib and the progression and after-effects of such studies. Galapagos cautions the clairvoyant that advanced statements are not guarantees of approaching performance. Advanced statements absorb accepted and alien risks, uncertainties and added factors which ability account the absolute results, banking activity and liquidity, achievement or achievements of Galapagos, or industry results, to be materially altered from any celebrated or approaching results, banking altitude and liquidity, achievement or achievements bidding or adumbrated by such advanced statements. In addition, alike if Galapagos’ results, performance, banking activity and liquidity, and the development of the industry in which it operates are constant with such advanced statements, they may not be predictive of after-effects or developments in approaching periods.  Among the factors that may aftereffect in differences are the inherent uncertainties associated with aggressive developments, analytic balloon and artefact development activities and authoritative approval requirements (including that abstracts from the advancing and planned analytic analysis programs may not abutment allotment or added development of filgotinib due to safety, ability or added reasons), Galapagos’ assurance on collaborations with third parties (including its accord accomplice for filgotinib, Gilead), and ciphering the bartering abeyant of filgotinib. A added account and description of these risks, uncertainties and added risks can be begin in Galapagos’ Securities and Exchange Commission (SEC) filings and reports, including in Galapagos’ best contempo anniversary address on anatomy 20-F filed with the SEC and consecutive filings and letters filed by Galapagos with the SEC.  Given these uncertainties, the clairvoyant is brash not to abode any disproportionate assurance on such advanced statements. These advanced statements allege alone as of the date of advertisement of this document. Galapagos especially disclaims any obligation to amend any such advanced statements in this certificate to reflect any change in its expectations with attention thereto or any change in events, altitude or affairs on which any such account is based or that may affect the likelihood that absolute after-effects will alter from those set alternating in the advanced statements, unless accurately appropriate by law or regulation.

Gilead Forward-Looking StatementThis columnist absolution includes advanced statements aural the acceptation of the Private Securities Litigation Reform Act of 1995 that are accountable to risks, uncertainties and added factors, including the achievability of abortive after-effects from advancing and added analytic trials involving filgotinib and the achievability that we are clumsy to complete one or added of such trials on the currently advancing timelines. Further, it is accessible that the parties may accomplish a cardinal accommodation to abandon development of filgotinib, and as a result, filgotinib may never be auspiciously commercialized. All statements added than statements of absolute actuality are statements that could be accounted advanced statements. These risks, uncertainties and added factors could account absolute after-effects to alter materially from those referred to in the advanced statements. The clairvoyant is cautioned not to await on these advanced statements. These and added risks are declared in detail in Gilead’s Quarterly Address on Anatomy 10-Q for the division concluded June 30, 2018, as filed with the U.S. Securities and Exchange Commission. All advanced statements are based on advice currently accessible to Gilead, and Gilead assumes no obligation to amend any such advanced statements.

Galapagos Contacts

Investors:                                                                     Media:

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Elizabeth Goodwin                                                      Evelyn Fox

VP IR & Corporate Communications                        Director Communications

1-781-460-1784                                                        31 6 53 591 999

E-mail: [email protected]                                                   E-mail:              [email protected]

 

Sofie Van Gijsel

Director IR

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32 485 191415

E-mail: [email protected]

 

Gilead Contacts

Investors:                                                                     Media:

Sung Lee                                                                      Nathan Kaiser

1 650-524-7792           1 650-522-1853

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